If the same iv line is used for sequential infusion of several drugs, flush the line before and after infusion of this drug with an infusion solution compatible to all drugs. Tigecycline is currently approved in north america for the treatment of adults with complicated skin. Tigecycline is active against grampositive and gramnegative bacteria, including tetracyclineresistant organisms, and some anaerobes. Tygacil is not indicated for treatment of diabetic foot infection or hospitalacquired pneumonia, including ventilatorassociated pneumonia.
Both tigecycline and the novel formulation reduced tumor volume and. The iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. Does tigecycline have a place in therapy for hospital. Thus, 5 ml of reconstituted solution is equivalent to 50 mg of the drug. Tigecycline is the first drug in the glycylcycline class of antibiotics. All patients received iv tigecycline for a minimum of 3 consecutive days to a maximum of 14 consecutive days, with the option to be switched to an oral antibiotic on or after day 4. Full text monographs for most every injectable drug available are reported in the complete king guide to parenteral admixtures.
Thus, tigecycline may have activity against tetracyclineresistant organisms. Results the use of iv andor ivt tigecycline was described in 39 patients infected with healthcareassociated a. In addition to updating drug interactions, precautions, alerts, and patient teaching instructions for all existing iv drugs, this new 36th edition includes over a dozen new monographs of the most recent iv drugs. This prevents formation of peptide chains in bacteria, thus interfering with their growth.
Trissel, fashp, 2010, american society of healthsystem pharmacists. In a pooled analysis of these trials, based on a random effects model by trial weight, an adjusted risk difference of allcause mortality was 0. Tigecycline is a glycylcycline antibiotic derived from the tetracycline group, that acts by inhibiting protein synthesis at the level of the bacterial ribosome. In an openlabel, ascending multipledose study, 39 children aged 8 to 11 years with ciai or cssti were administered tigecycline 0. Intermittent an infusion from a burette or minibag running over approximately 1560 minutes. Children younger than 8 years may be more sensitive to the side effects of tigecycline, especially tooth discoloration.
Tigecycline in saline and the novel formulation were prepared fresh twice a day. Incompatibilities are based on meeting any of the following criteria. Each vial of tygacil should be reconstituted with 5. Additive compatibility drugs in syringe compatibility.
Tigecycline inhibits protein production in bacteria by binding to the 30s ribosomal subunit and blocking entry of transfer rna molecules into the ribosome of the bacteria. But you must use the medicine within 24 hours up to 6 hours in the vial and the other 18 hours in the iv bag. However, because of its extensive distribution into tissue, high blood levels are not maintained, so tigecycline is probably not a good choice for patients with bacteremia. The tigecycline regimen was noninferior to the imipenemcilastatin group for nonvap, but did not meet the. Potassium chloride, propofol, ropivacaine, tigecycline, ziconotide, and zidovudine. Side effects of tygacil tigecycline, warnings, uses. Essential coverage of 48 of the most common and complex iv drugs, including drip rate calculation charts, drug calculation formulae, and much more help you safely and efficiently administer iv drugs. Usual duration of therapy is 5 14 days, although actual duration should be dictated by the site and severity of infection and the patients overall clinical status. The recommended dose of tigecycline is 100 mg iv bolus followed by 50 mg iv every 12 hours to be delivered over 30 to 60 minutes. Tooth discoloration has also occurred in older children and in young adults.
Continuous an infusion running over more than 1 hour. Although it is structurally related to minocycline, alterations to the molecule resulted in its expanded spectrum of activity and decreased susceptibility to the development of resistance when compared with other tetracycline antibiotics. Food and drug administration 10903 new hampshire avenue silver spring, md 20993 1888infofda 18884636332 contact fda. Tigecycline is a glycylcycline antibacterial structurally related to the tetracyclines. If the same iv line is used for sequential infusion of several drugs, flush line with ns, d5w, or lr before and after tigecycline administration. In addition to updating drug interactions, precautions, alerts, and patient teaching.
Tigecycline is a prescription medication used to treat serious skin and stomach infections and certain types of pneumonia lung infection. Each monograph contains stability data, administration guidelines, and methods of preparation. Tygacil tigecycline is a tetracyclinelike antibiotic used to treat many different bacterial infections of the skin or the digestive system. Intravenous compatibility chart drug information for the. It displays broadspectrum, potent activity against both grampositive and gramnegative bacteria, including many multidrugresistant pathogens. It is also active against meticillinresistant staphylococcus aureus and vancomycinresistant enterococci, but pseudomonas aeruginosa and many strains of proteus spp are resistant to tigecycline. Tigecycline is an antibiotic for a number of bacterial infections. For the treatment of complicated intraabdominal infections due to susceptible isolates of citrobacter freundii, enterobacter cloacae, escherichia coli, klebsiella oxytoca, k pneumoniae. Critical care admixtures wall chart list of iv drugs. Healthy subjects received a single 100 mg iv dose of tigecycline followed by 50 mg iv q 12 h. Intravenous compatibility chart acyclovir acyclovir.
Mixed medicine in an iv bag may be kept at cool room temperature. Detailed listing of the iv drug compatibility and stability updates applied to the king guide to parenteral admixtures over the last 12 years. It is also active against meticillinresistant staphylococcus aureus and vancomycinresistant enterococci. Intravenous admixtures preparation and infusion guidelines. Tigecycline tygacil is an antibiotic used to treat complicated skin infections caused by susceptible strains of bacteria, for treating complicated intraabdominal infections caused by susceptible strains of bacteria, and to treat communityacquired bacterial pneumonia. A novel formulation of tigecycline has enhanced stability. Administer iv infusions over about 30 to 60 minutes.
If the same iv line is used for sequential infusion of several different drugs, the line should be flushed before and after infusion of tigecycline with an infusion solution compatible with tigecycline and with any other drugs administered via this common line, such as 0. Reconstituted solution must be transferred and further diluted for iv infusion. Infuse over 30 to 60 minutes through dedicated line or via ysite. Tigecycline injection may make your skin sensitive to sunlight or ultraviolet light. Home explore intravenous compatibility chart drug information for the. Tigecycline for severe clostridium difficile infection. Tygacil tigecycline dose, indications, adverse effects.
This reference contains standard dilutions including iv admixture drug concentration, infusion volumes, and infusion rates. It was developed in response to the growing rate of antibiotic resistant bacteria such as staphylococcus aureus, acinetobacter baumannii, and e. Tigecycline shows higher binding affinity than tetracyclines, being active against bacterial strains with either mechanism of tetracycline resistance efflux and ribosomal protection. Store in the iv bag at room temperature for up to 6 h, or refrigerated at 2. Tigecycline has a reduced potential for resistance, as it is not affected by the two major mechanisms of tetracycline resistance. A handbook for nurses and health professionals has been a trusted resource for comprehensive drug coverage, unparalleled accuracy, and an intuitive quickaccess format. The following is the list of drugs found on the king guide to parenteral admixtures critical care admixtures wall chart. The essential information you need to safely administer more than 400 intravenous drugs. Intravenous iv preparation and infusion guidelines globalrph. Tygacil 50mg powder for solution for infusion summary of. Find information about common, infrequent and rare side effects of tigecycline intravenous. Complicated skin and skin structure infections complicated intraabdominal infections communityacquired bacterial pneumonia limitations of use. Common and rare side effects for tigecycline intravenous.
Intravenous injection introduced directly into a vein or a freely flowing iv line. Intravenous compatibility chart free html5 flip book. Tygacil tigecycline side effects, images, uses, dosage. The cause of this increase has not been established. Tygacil is a tetracycline class antibacterial indicated in patients 18 years of age and older for. Renal dose adjustment guidelines for antimicrobials crrt.
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